Inattention and reaction time variability are linked to ventromedial prefrontal volume in adolescents
dc.contributor.author | Albaugh, Matthew D. | |
dc.contributor.author | Orr, Catherine | |
dc.contributor.author | Chaarani, Bader | |
dc.contributor.author | Althoff, Robert R. | |
dc.contributor.author | Allgaier, Nicholas | |
dc.contributor.author | D’Alberto, Nicholas | |
dc.contributor.author | Hudson, Kelsey | |
dc.contributor.author | Mackey, Scott | |
dc.contributor.author | Spechler, Philip A. | |
dc.contributor.author | Banaschewski, Tobias | |
dc.contributor.author | Brühl, Rüdiger | |
dc.contributor.author | Bokde, Arun W. L. | |
dc.contributor.author | Bromberg, Uli | |
dc.contributor.author | Büchel, Christian | |
dc.contributor.author | Cattrell, Anna | |
dc.contributor.author | Conrod, Patricia | |
dc.contributor.author | Desrivières, Sylvane | |
dc.contributor.author | Flor, Herta | |
dc.contributor.author | Frouin, Vincent | |
dc.contributor.author | Gallinat, Jürgen | |
dc.contributor.author | Goodman, Robert | |
dc.contributor.author | Gowland, Penny | |
dc.contributor.author | Grimmer, Yvonne | |
dc.contributor.author | Heinz, Andreas | |
dc.contributor.author | Kappel, Viola | |
dc.contributor.author | Martinot, Jean-Luc | |
dc.contributor.author | Paillère-Martinot, Marie-Laure | |
dc.contributor.author | Nees, Frauke | |
dc.contributor.author | Papadopoulos Orfanos, Dimitri | |
dc.contributor.author | Penttiä, Jani | |
dc.contributor.author | Poustka, Luise | |
dc.contributor.author | Paus, Tomáš | |
dc.contributor.author | Smolka, Michael N. | |
dc.contributor.author | Struve, Maren | |
dc.contributor.author | Walter, Henrik | |
dc.contributor.author | Whelan, Robert | |
dc.contributor.author | Schumann, Gunter | |
dc.contributor.author | Garavan, Hugh | |
dc.contributor.author | Potter, Alexandra S. | |
dc.date.accessioned | 2020-05-05T13:48:58Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2020-05-05T13:48:58Z | |
dc.date.issued | 2017-01-13 | |
dc.identifier.uri | http://hdl.handle.net/1866/23324 | |
dc.publisher | Elsevier | fr |
dc.subject | Attention-deficit/hyperactivity disorder | fr |
dc.subject | Neuroimaging | fr |
dc.subject | Ventromedial prefrontal cortex | fr |
dc.subject | Inattention | fr |
dc.subject | Reaction time variability | fr |
dc.subject | Multi-informant | fr |
dc.title | Inattention and reaction time variability are linked to ventromedial prefrontal volume in adolescents | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de psychiatrie et d'addictologie | fr |
dc.identifier.doi | 10.1016/j.biopsych.2017.01.003 | |
dcterms.abstract | Background Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have most commonly reported volumetric abnormalities in the basal ganglia, cerebellum, and prefrontal cortices. Few studies have examined the relationship between ADHD symptomatology and brain structure in population-based samples. We investigated the relationship between dimensional measures of ADHD symptomatology, brain structure, and reaction time variability—an index of lapses in attention. We also tested for associations between brain structural correlates of ADHD symptomatology and maps of dopaminergic gene expression. Methods Psychopathology and imaging data were available for 1538 youths. Parent ratings of ADHD symptoms were obtained using the Development and Well-Being Assessment and the Strengths and Difficulties Questionnaire (SDQ). Self-reports of ADHD symptoms were assessed using the youth version of the SDQ. Reaction time variability was available in a subset of participants. For each measure, whole-brain voxelwise regressions with gray matter volume were calculated. Results Parent ratings of ADHD symptoms (Development and Well-Being Assessment and SDQ), adolescent self-reports of ADHD symptoms on the SDQ, and reaction time variability were each negatively associated with gray matter volume in an overlapping region of the ventromedial prefrontal cortex. Maps of DRD1 and DRD2 gene expression were associated with brain structural correlates of ADHD symptomatology. Conclusions This is the first study to reveal relationships between ventromedial prefrontal cortex structure and multi-informant measures of ADHD symptoms in a large population-based sample of adolescents. Our results indicate that ventromedial prefrontal cortex structure is a biomarker for ADHD symptomatology. These findings extend previous research implicating the default mode network and dopaminergic dysfunction in ADHD. | fr |
dcterms.isPartOf | urn:ISSN:0006-3223 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Albaugh, M. D., Orr, C., Chaarani, B., Althoff, R. R., Allgaier, N., D’Alberto, N., ... & Brühl, R. (2017). Inattention and reaction time variability are linked to ventromedial prefrontal volume in adolescents. Biological psychiatry, 82(9), 660-668. | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Biological psychiatry | |
oaire.citationVolume | 82 | |
oaire.citationIssue | 9 | |
oaire.citationStartPage | 660 | |
oaire.citationEndPage | 668 |
Files in this item
This item appears in the following Collection(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.