Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm
dc.contributor.author | Duclos, Catherine | |
dc.contributor.author | Dumont, Marie | |
dc.contributor.author | Paquet, Jean | |
dc.contributor.author | Blais, Hélène | |
dc.contributor.author | Van der Maren, Solenne | |
dc.contributor.author | Menon, David K. | |
dc.contributor.author | Bernard, Francis | |
dc.contributor.author | Gosselin, Nadia | |
dc.date.accessioned | 2019-11-05T18:44:16Z | |
dc.date.available | MONTHS_WITHHELD:12 | fr |
dc.date.available | 2019-11-05T18:44:16Z | |
dc.date.issued | 2019-09-28 | |
dc.identifier.uri | http://hdl.handle.net/1866/22408 | |
dc.publisher | Oxford University Press | fr |
dc.subject | Sleep | fr |
dc.subject | Circadian rhythms | fr |
dc.subject | Traumatic brain injury | fr |
dc.subject | Melatonin | fr |
dc.subject | Actigraphy | fr |
dc.subject | Acute care | fr |
dc.title | Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté des arts et des sciences. Département de psychologie | fr |
dc.identifier.doi | 10.1093/sleep/zsz191 | |
dcterms.abstract | Study Objectives: To test whether the sleep-wake cycle disruption in patients hospitalized with traumatic brain injury (TBI) 1) is also found in patients with traumatic injuries other than TBI (nonTBI); and 2) is associated to a weaker or abnormal circadian clock signal. Methods: Forty-two non-mechanically ventilated and non-sedated patients hospitalized for moderate to severe TBI were compared to 34 non-TBI patients. They wore wrist actigraphs for 9.4±4.2 days, starting 19.3±12.6 days post-injury. Of these, 17 TBI and 14 non-TBI patients had their urine collected every hour for 25 h, starting 18.3±12.3 days post-injury. We calculated urinary 6-sulfatoxymelatonin concentration to obtain total 24 h excretion, excretion onset, offset, duration, amplitude and acrophase. Using Student’s t-tests, we compared groups on actigraphy (daytime activity ratio, nighttime total sleep time, and fragmentation index) and melatonin variables. We investigated associations between melatonin and actigraphy variables using Pearson’s correlations. Results: TBI patients had poorer daytime activity ratio (TBI: 77.5±9.4%; non-TBI: 84.6±6.9%), shorter nighttime total sleep time (TBI: 353.5±96.6 min; non-TBI: 421.2±72.2 min), and higher fragmentation index (TBI: 72.2±30.0; non-TBI: 53.5±23.6) (all p-values<0.01). A melatonin rhythm was present in both groups, and no group differences were found on melatonin variables. No associations were found between melatonin and actigraphy variables in TBI patients. Conclusion: Moderate to severe TBI patients have more serious sleep-wake disturbances than non-TBI patients hospitalized in the same environment, suggesting that the brain injury itself alters the sleepwake cycle. Despite their deregulated 24 h sleep-wake cycle, TBI patients have a normal circadian clock signal. | fr |
dcterms.isPartOf | urn:ISSN: 0161-8105 | fr |
dcterms.isPartOf | urn:ISSN:1550-9109 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | PMID: 31562742 DOI: 10.1093/sleep/zsz191 | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Sleep |
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