Association between waking electroencephalography and cognitive event-related potentials in patients with obstructive sleep apnea
EEG and ERP in OSA
Article [Accepted Manuscript]
Abstract(s)
Objective: Abnormal event-related potentials (ERP) and slowing of the waking
electroencephalographic (EEG) activity have been reported in patients with obstructive
sleep apneas (OSA). This study aimed at evaluating whether an association exists
between the severity of ERP abnormalities and EEG slowing in order to better understand
cerebral dysfunction in OSA.
Methods: Twelve OSA patients and 12 age-matched controls underwent an overnight
polysomnographic recording, an EEG recording of 10 minutes of wakefulness and an
auditory ERP protocol known to specifically measure attention. Amplitude and latency of
each ERP component were measured as well as the spectral power in each frequency
band of the waking EEG. Pearson’s correlations were used to measure associations
between ERP characteristics and EEG spectral power in OSA patients and control
subjects.
Results: A positive correlation between the late P300 amplitude and theta power in
occipital region was observed in OSA subjects (p<0.01). A positive correlation was also
found between P3a amplitude and beta 1 power in central region in OSA subjects
(p<0.01). No correlation was observed for control subjects.
Conclusions: ERP abnormalities observed in an attention task are associated with a
slowing of the waking EEG recorded at rest in OSA.
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