An astrocyte-dependent mechanism for neuronal rhythmogenesis
dc.contributor.author | Morquette, Philippe | |
dc.contributor.author | Verdier, Dorly | |
dc.contributor.author | Kadala, Aklesso | |
dc.contributor.author | Féthière, James | |
dc.contributor.author | Philippe, Antony G. | |
dc.contributor.author | Robitaille, Richard | |
dc.contributor.author | Kolta, Arlette | |
dc.date.accessioned | 2018-01-19T14:43:14Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2018-01-19T14:43:14Z | |
dc.date.issued | 2015-06 | |
dc.identifier.uri | http://hdl.handle.net/1866/19737 | |
dc.title | An astrocyte-dependent mechanism for neuronal rhythmogenesis | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine dentaire | fr |
UdeM.statut | Professeur(e) / Professor | fr |
dc.identifier.doi | 10.1038/nn.4013 | |
dcterms.abstract | Communication between neurons rests on their capacity to change their firing pattern to encode different messages. For several vital functions, such as respiration and mastication, neurons need to generate a rhythmic firing pattern. Here we show in the rat trigeminal sensori-motor circuit for mastication that this ability depends on regulation of the extracellular Ca2+ concentration ([Ca2+]e) by astrocytes. In this circuit, astrocytes respond to sensory stimuli that induce neuronal rhythmic activity, and their blockade with a Ca2+ chelator prevents neurons from generating a rhythmic bursting pattern. This ability is restored by adding S100b, an astrocytic Ca2+-binding protein, to the extracellular space, while application of an anti-S100b antibody prevents generation of rhythmic activity. These results indicate that astrocytes regulate a fundamental neuronal property: the capacity to change firing pattern. These findings may have broad implications for many other neural networks whose functions depend on the generation of rhythmic activity. | fr |
dcterms.isPartOf | urn:ISSN:1546-1726 | |
dcterms.isPartOf | urn:ISSN:1097-6256 | |
dcterms.language | eng | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Nature neuroscience | |
oaire.citationVolume | 18 | |
oaire.citationIssue | 6 | |
oaire.citationStartPage | 844 | |
oaire.citationEndPage | 854 |
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