An astrocyte-dependent mechanism for neuronal rhythmogenesis
dc.contributor.author | Morquette, Philippe | |
dc.contributor.author | Verdier, Dorly | |
dc.contributor.author | Kadala, Aklesso | |
dc.contributor.author | Féthière, James | |
dc.contributor.author | Philippe, Antony G. | |
dc.contributor.author | Robitaille, Richard | |
dc.contributor.author | Kolta, Arlette | |
dc.date.accessioned | 2018-01-19T14:43:14Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2018-01-19T14:43:14Z | |
dc.date.issued | 2015-06 | |
dc.identifier.uri | http://hdl.handle.net/1866/19737 | |
dc.title | An astrocyte-dependent mechanism for neuronal rhythmogenesis | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine dentaire | fr |
UdeM.statut | Professeur(e) / Professor | fr |
dc.identifier.doi | 10.1038/nn.4013 | |
dcterms.abstract | Communication between neurons rests on their capacity to change their firing pattern to encode different messages. For several vital functions, such as respiration and mastication, neurons need to generate a rhythmic firing pattern. Here we show in the rat trigeminal sensori-motor circuit for mastication that this ability depends on regulation of the extracellular Ca2+ concentration ([Ca2+]e) by astrocytes. In this circuit, astrocytes respond to sensory stimuli that induce neuronal rhythmic activity, and their blockade with a Ca2+ chelator prevents neurons from generating a rhythmic bursting pattern. This ability is restored by adding S100b, an astrocytic Ca2+-binding protein, to the extracellular space, while application of an anti-S100b antibody prevents generation of rhythmic activity. These results indicate that astrocytes regulate a fundamental neuronal property: the capacity to change firing pattern. These findings may have broad implications for many other neural networks whose functions depend on the generation of rhythmic activity. | fr |
dcterms.isPartOf | urn:ISSN:1546-1726 | |
dcterms.isPartOf | urn:ISSN:1097-6256 | |
dcterms.language | eng | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Nature neuroscience | |
oaire.citationVolume | 18 | |
oaire.citationIssue | 6 | |
oaire.citationStartPage | 844 | |
oaire.citationEndPage | 854 |
Files in this item
This item appears in the following Collection(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.