Synthesis of (S)-cEt-LNA
| dc.contributor.advisor | Hanessian, Stephen | |
| dc.contributor.author | Salinas Hernandez, Juan Carlos | |
| dc.date.accessioned | 2014-10-08T18:20:59Z | |
| dc.date.available | NO_RESTRICTION | fr |
| dc.date.available | 2014-10-08T18:20:59Z | |
| dc.date.issued | 2014-09-29 | |
| dc.date.submitted | 2014-04 | |
| dc.identifier.uri | http://hdl.handle.net/1866/11229 | |
| dc.subject | (S)-cEt-LNA | fr |
| dc.subject | Technologie antisens | fr |
| dc.subject | Nucleoside | fr |
| dc.subject | Antisense technology | fr |
| dc.subject.other | Chemistry - Organic / Chimie organique (UMI : 0490) | fr |
| dc.title | Synthesis of (S)-cEt-LNA | fr |
| dc.type | Thèse ou mémoire / Thesis or Dissertation | |
| etd.degree.discipline | Chimie | fr |
| etd.degree.grantor | Université de Montréal | fr |
| etd.degree.level | Maîtrise / Master's | fr |
| etd.degree.name | M. Sc. | fr |
| dcterms.abstract | Nucleoside (S)-cEt-LNA a été synthétisé par trois voies différentes à partir de la 5- méthyluridine qui est commercialement disponible. Le chemin le plus court comprend une méthylation diastéréosélective d'un aldéhyde, et une cyclisation 5-exo-tet d'un éther par déplacement SN2. | fr |
| dcterms.abstract | (S)-cEt-LNA nucleoside was synthesized by three different routes starting from commercially available 5-methyluridine. The shortest route includes a diastereoselective methylation of an aldehyde, and a 5-exo-tet cylization of an ether via SN2 displacement. | fr |
| dcterms.language | eng | fr |
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